You can have noiseless streams using Krisp with OBS Studio.
After you download and install Krisp, configuring with OBS is super simple.
1. Select Krisp as a microphone & speaker
Open Audio settings in OBS Studio and select Krisp microphone and speaker.
2. Mute the Noise
Choose the correct microphone in Krisp menu. Make sure that Mute Noise toggle is turned on in Krisp UI.
The "in use" indicator will be On if there is an ongoing stream.
3. Start your stream
Start and enjoy your noiseless OBS stream!
Here's a quick video tutorial to help you along the way
Krisp with OBS on Mac
Krisp with OBS on Windows